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Figure 1: Augmentation of cytotoxic activity of murine natural killer (NK) cell by keyhole limpet hemocyanin (KLH) in vitro. C57BL/6 mice NK cells enriched by negative selection were cultured for 24 h with the indicated doses of KLH (a) for the indicated periods with or without 25 μg/mL of KLH (b). The cytotoxic activity of NK cells against yeast artificial chromosome (YAC)-1 tumor cells was determined. The data are means ± standard error of the mean (SEM) of three independent experiments (a) or representative of two separate experiments with similar results (b). *P < 0.05, **P < 0.01, and ***P < 0.001, as compared with the values of control cultures incubated in medium alone (Dunnett's t-test)

Figure 1: Augmentation of cytotoxic activity of murine natural killer (NK) cell by keyhole limpet hemocyanin (KLH) <i>in vitro</i>. C57BL/6 mice NK cells enriched by negative selection were cultured for 24 h with the indicated doses of KLH (a) for the indicated periods with or without 25 μg/mL of KLH (b). The cytotoxic activity of NK cells against yeast artificial chromosome (YAC)-1 tumor cells was determined. The data are means ± standard error of the mean (SEM) of three independent experiments (a) or representative of two separate experiments with similar results (b). *<i>P</i> < 0.05, **<i>P</i> < 0.01, and ***<i>P</i> < 0.001, as compared with the values of control cultures incubated in medium alone (Dunnett's <i>t</i>-test)