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Figure 5 :(A) Incubation with Cleistanthus collinus extract decreases ATPase activity of both brush border (BBM) and basolateral membranes (BLM) of rat kidney (n = 4, P < 0.001 with WSR test in both cases). (B) N-ethyl maleimide (NEM), a known proton pump blocker, also inhibited ATPase activity of both BBM and BLM as compared to the vehicle DMSO, in which it was dissolved (n = 4, P = 0.03 with WSR test). (C) Ouabain, a known sodium–potassium pump blocker, did not inhibit the ATPase activities of both BBM and BLM (P = 1 for BLM, n = 6 and P = 0.2 for BBM, n = 9).

Figure 5 :(A) Incubation with Cleistanthus collinus extract decreases ATPase activity of both brush border (BBM) and basolateral membranes (BLM) of rat kidney (n = 4, P < 0.001 with WSR test in both cases). (B) N-ethyl maleimide (NEM), a known proton pump blocker, also inhibited ATPase activity of both BBM and BLM as compared to the vehicle DMSO, in which it was dissolved (n = 4, P = 0.03 with WSR test). (C) Ouabain, a known sodium–potassium pump blocker, did not inhibit the ATPase activities of both BBM and BLM (P = 1 for BLM, n = 6 and P = 0.2 for BBM, n = 9).