Indian J Pharm Close
 

Figure 1 :HPLC analysis of imatinib: (a) Chromatogram showing the absence of interference between acetaminophen and imatinib; (b) Chromatogram of a blank plasma sample showing the lack of matrix interference; (c) Chromatogram of a plasma sample at 40 min after coadministration of acetaminophen (700 mg/kg, IP) and imatinib (100 mg/kg, PO). The additional peaks at 3.6 and 5.5 min are likely to be imatinib metabolites.

Figure 1 :HPLC analysis of imatinib: (a) Chromatogram showing the absence of interference between acetaminophen and imatinib; (b) Chromatogram of a blank plasma sample showing the lack of matrix interference; (c) Chromatogram of a plasma sample at 40 min after coadministration of acetaminophen (700 mg/kg, IP) and imatinib (100 mg/kg, PO). The additional peaks at 3.6 and 5.5 min are likely to be imatinib metabolites.