Figure 3: Effect of flavonoids in comparison to tocopherol acetate (200 mg/kg, i.p.) against percutaneously administered SM (2 LD50) on mice spleen. Flavonoids and tocopherol acetate were administered simultaneously with SM. The animals were sacrificed seven days post SM administration. Q = quercetin; G = gossypin; HR = H. rhamnoides flavone; TA = tocopherol acetate. H&E, x100. (a) Control spleen showing normal splenic parenchyma germinal centre, red and white pulp, (b) SM administered mice spleen (2 LD50) showing congestion, hypocellularity and parenchymal degeneration, (c) Quercetin administration with SM showing protection with lesser hypocellularity, (d) Gossypin administration with SM showing lesser magnitude of splenic degeneration,(e) HR-flavone administration with SM showing minimal lesions, (f) Tocopherol acetate administration with SM showing marginal protection.