Figure 2: Effect of flavonoids in comparison to tocopherol acetate (200 mg/kg, i.p.) against percutaneously administered SM (2 LD50) on mice liver. Flavonoids and tocopherol acetate were administered simultaneously with SM. The animals were sacrifi ced seven days post SM administration. Q = quercetin; G = gossypin; HR = H. rhamnoides flavone; TA = tocopherol acetate. H&E, x100. (a) Control liver showing normal hepatic parenchyma, hepatic lobules and hepatocytes, (b) SM administered mice liver (2 LD50) showing granulovacuolar degeneration and perinuclear clumping of cytoplasm, (c) Quercetin administration with SM, showing reduced hepatic lesions,(d) Gossypin administration with SM showing lesser magnitude of hepatic lesions, (e) HR-flavone administration with SM showing protection of hepatic degeneration, (f) Tocopherol acetate administration with SM showing marginal protection.