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Figure 1: Effect of fl avonoids in comparison to tocopherol acetate (200 mg/kg, i.p.) against percutaneously administered SM (2 LD50). Q = quercetin; G = gossypin; HR = H. rhamnoides flavone; TA = tocopherol acetate. Mean SE (n = 4); Flavonoids and tocopherol acetate were administered simultaneously with SM. The animals were sacrificed seven days post SM administration. a - Significantly different from control group; b - Significantly different from SM group. Control values: Antioxidant status (plasma) = 139.0 4.9 M Glutathione Peroxidase (liver) = 747 19 nanomoles of NADPH/min/mg protein Glutathione Reductase (liver) = 43.5 1.2 nanomoles NADPH/min/mg protein Superoxide Dismutase (liver) = 5.60 0.56 U/ mg proteinFigure 1: Effect of flavonoids in comparison to tocopherol acetate (200 mg/kg, i.p.) against percutaneously administered SM (2 LD50). Q = quercetin; G = gossypin; HR = H. rhamnoides flavone; TA = tocopherol acetate. Mean SE (n = 4); Flavonoids and tocopherol acetate were administered simultaneously with SM. The animals were sacrificed seven days post SM administration. a - Significantly different from control group; b - Significantly different from SM group. Control values: Antioxidant status (plasma) = 139.0 4.9 M Glutathione Peroxidase (liver) = 747 19 nanomoles of NADPH/min/mg protein Glutathione Reductase (liver) = 43.5 1.2 nanomoles NADPH/min/mg protein Superoxide Dismutase (liver) = 5.60 0.56 U/ mg protein

Figure 1: Effect of fl avonoids in comparison to tocopherol acetate (200 mg/kg, i.p.) against percutaneously administered SM (2 LD50). Q = quercetin; G = gossypin; HR = H. rhamnoides flavone; TA = tocopherol acetate. Mean  SE (n = 4); Flavonoids and tocopherol acetate were administered simultaneously with SM. The animals were sacrificed seven days post SM administration. a - Significantly different from control group; b - Significantly different from SM group. Control values: Antioxidant status (plasma) = 139.0  4.9  M Glutathione Peroxidase (liver) = 747  19 nanomoles of NADPH/min/mg protein Glutathione Reductase (liver) = 43.5  1.2 nanomoles NADPH/min/mg protein Superoxide Dismutase (liver) = 5.60  0.56 U/ mg proteinFigure 1: Effect of flavonoids in comparison to tocopherol acetate (200 mg/kg, i.p.) against percutaneously administered SM (2 LD50). Q = quercetin; G = gossypin; HR = H. rhamnoides flavone; TA = tocopherol acetate. Mean  SE (n = 4); Flavonoids and tocopherol acetate were administered simultaneously with SM. The animals were sacrificed seven days post SM administration. a - Significantly different from control group; b - Significantly different from SM group. Control values: Antioxidant status (plasma) = 139.0  4.9 M Glutathione Peroxidase (liver) = 747  19 nanomoles of NADPH/min/mg protein Glutathione Reductase (liver) = 43.5  1.2 nanomoles NADPH/min/mg protein Superoxide Dismutase (liver) = 5.60  0.56 U/ mg protein