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   1982| April-June  | Volume 14 | Issue 2  
 
 
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SHORT COMMUNICATION
Antispermatogenic effect of embelin from Embelia ribes
SD Seth, Johri Nera, KR Sundran
April-June 1982, 14(2):207-211
Embelin from Embelia ribes significantly reduced the sperm count and motility and also the weight of the testes, in albino rats.
[ABSTRACT]   Full text not available  [PDF]
  2,046 274 -
RESEARCH PAPER
Anti-histaminic activity of a mannich base b-dimethyl aminoethyl p-chlorophenyl ketone HCl
SC Chaturvedi, GK Patnaik, BN Dhawan
April-June 1982, 14(2):159-162
(-dimethylamino ethyl p-chloro phenyl ketone hydrochloride, a para substituted acetophenone Mannich base showed marked antihiitaminic (Hz) activity in various in vivo and in vitro test models. It selectively antagonised the histamine incuded vasodepressor activity in anaesthetised cat, broncho -constriction in guinea - pig and spasm of guinea-pig ileum in a dose dependent manner. The compound failed to inhibit the H2-receptor Mediated positive chronotropic, but could completely abolish the positive inotropy on the isolated guinea - pig atrium. The compound was however found to be less potent than diphenhydramine.
[ABSTRACT]   Full text not available  [PDF]
  1,461 146 -
RESEARCH PAPER
Skin window test in drug allergy
R Panneerselvam, BR Garg, Lal Sardari
April-June 1982, 14(2):201-206
> Skin window test was performed in nineteen eases of drug allergy and nine non-allergic controls with the causative drugs as proved by the provocation test. Eleven (57 9 %) out of nineteen drug allergy cases showed a significant increase in eosinophils at drug test sites as compared with the control sites, while none of the non-allergic individuals showed such an increase. Skin window test was found useful to prove diagnosis of drug allergy in 57.9% cases studied. Performing of skin window cell counts beyond 24 h may be useful in detecting cases of drug allergy showing negative skin window teats upto 24 h.
[ABSTRACT]   Full text not available  [PDF]
  1,505 98 -
An experimental study of quercetin in lenticular opacities
P Sharma, AL Sharma, S Kulshreshtha, SS Mishra, DN Pandey
April-June 1982, 14(2):169-175
Quercetin, a flavonoid, is a known lens aldose reductase inhibitor. When administered orally, it causes a significant delay in the initiation and. Develoment of experimentally induced galactosaemic and naphthalene cataract. These observations support the hypothesis that in galactosaemia and diabetes, aldose reductase plays a key role in the formation of cataract. Flavonoids, like qurecetin, may be therefore useful in inhibiting the devlopment of cataract in diabetes.
[ABSTRACT]   Full text not available  [PDF]
  1,190 129 -
RESEARCH PAPER
Synthesis and CNS activity of 4-Aryl-1-p [(substituted benzamido)-benzoyl]-piperazine
Agarwal Rajesh, MK Shukla, RK Satsangi
April-June 1982, 14(2):177-182
Twelve title compounds (III) were synthesised by the aroylation of the 4-aryl-1-(p-amino benzoyl)-piperaxines (I I), which have, inturn, been prepared by the reduction of respective 4-aryl I-(p-nitro benzoyl)-piperazines (I). The structures of the new compounds were confirmed by elemental analysis and the IR and PMR spectroscopy. Eight of the title compounds were found to be CNS stimulants and the rest four, CNS depressants.
[ABSTRACT]   Full text not available  [PDF]
  1,167 118 -
RESEARCH PAPER
A study of anticonvulsant activity of N-substituted derivatives of 1-anilinocycloxane-1-amide
SN Mukhopadhyay, SK Bhattacharya, YV Rao, PK Das
April-June 1982, 14(2):191-199
Eleven N-substituted derivatives of l-anilinocyclohexane-l-amide and l-p -anisidino cyclohexane-I-amide with different side chains viz. dimethylamino, di-n-butylamino, dibenzylamino, piperidino, pyrrolidino and morpholino moieties were synthesised using Mannich reaction. Anticonvulsant activity of these compounds was studied against electroshock and metrazol seizures in albino rats and against strychnine convulsions in frogs. Out of the eleven test compounds, significant protection was observed with six compounds against electroshock seizures and with eight compounds against metrazol seizures. Dibenzylamino and morpholino derivatives of both 1-anilino and 1-p-anisidino moieties showed protection against electroshock and metrazol induced convulsions. None of the test compounds antagonised strychnine convulsions in frogs. Most of the compounds that showed anticonvulsant activity produced sedation and potentiated pentobarbitone hypnosis in albino rats.
[ABSTRACT]   Full text not available  [PDF]
  1,109 149 -
L-valine as an anti-inflammatory agent
NK Khanna, P Jain, VK Pendse
April-June 1982, 14(2):149-158
1. L-valine, an amino acid, was found to have marked anti-inflammatory and moderate analgesic activity The drug was orally effective in inhibiting various experimentally induced inflammatory reactions and did not show any gastric irritation in anti-inflammatory doses, 2. It was observed that the anti-inflammatory effect of L-valine was not due to a counter irritant action.
[ABSTRACT]   Full text not available  [PDF]
  1,072 163 -
SHORT COMMUNICATION
Comparison between effectiveness of intramuscular and intravenous lignocaine on ventricular arrhythmia complicating acute, myocardial infarction
AK Gupta, P Porwol, NK Nuwal, MR Gagrani
April-June 1982, 14(2):213-215
Fifty patients with acute myocardial infarction were treated with lignocaine after developing ventricular tachyarrhythmias.25 patients received 75 mg as an intravenous bolus, immediately followed by an infusion of 2 mg/min and 25 patients received intramuscular treatment (300 mg.) There was no significant difference in the occurrence of tachyarrhythmia in the two groups for one hour, showing that, the dose of intramuscular lignocaine used was therapeutically effective against ventricular arrhythmias during myocardial infraction.
[ABSTRACT]   Full text not available  [PDF]
  1,147 81 -
RESEARCH PAPER
The effect of adrenoceptor blockers (propranolol and phenoxybenzamine) on single trial passive avoidance response in rats
N Jagdev, FSK Barar
April-June 1982, 14(2):143-148
Rats received a single training trial on a n inhibitory avoidance (passive avoidance) rats, and retention trials 24 h (R-I) and 48 h (R-II) later.The animals were subjected to 5 different trial, scheduld(s) : control, pre-trial, pre-trial plus pre-retention, pre-retention, and post-trial in a special two chambered apparatus, and the step-through latency was determined. Propranolol (6.5 mg/kg ip) increased the mean 'step-through latencies significantly in groups III & IV (P < 0.05 and group II & V (P<0.001) as compared to that in group I on R-I There was a similar increase in the retest lalatencies in groups II & III (P<0.01) and group IV & V(p <0.001), as compared to that is group I on R-II. Phenoxybenzamine (5.0 mg/kg ip) had an insignificant effect on the retest latenoes in all the groups both after 24 h and 48 h retention trials.
[ABSTRACT]   Full text not available  [PDF]
  1,143 77 -
RESEARCH PAPER
Kinetics of lithium in normal volunteers
CB Khare, A Sankaranarayanan, SK Khandelwal, KS Raghvan, R Srinivasamurthy
April-June 1982, 14(2):163-168
Six normal volunteers completed the study following oral administration of conventional and later slow release preparation of lithium carbonate. Mean serum levels over 24 h were calculated. The average time required to reach maximum concentration in serum was 5 h in conventional form and 6 h in case of slow release form. The maximum concentration did not differ significantly. The bio-availability of the conventional form was 79.9% of the slow release form. The volume of distribution and metabolic clearance rates for both the forms were similar. Implications of these findings are discussed.
[ABSTRACT]   Full text not available  [PDF]
  1,075 88 -
SHORT COMMUNICATION
Effect of restraint stress on morphine antinociception in rats
SK Bhattacharya, D Bhattacharya
April-June 1982, 14(2):217-222
The effect of restraint stress (1, 2 and 4 h ) was investigated, in rats, on the antinociceptive action of a sub-analgesic dose (2.0 mg/kg, ip) of morphine. Restraint stress prduced a time-related potentiation of morphine antinociception. Stress (4 h)-induced potentiation of morphine analgesia was significantly attenuated after pretreatment with pharmacological agents known to decrease serotonergic and prostaglandin activity, but not by metyrapone, an inhibitor of endogenous corticoid synthesis. The results suggest that serotonin and prostaglandins are involved in restraint stress-morphine interaction.The results have been discussed in the context of earlier investigations, reported from this laboratory, indicating increase in rat brain serotonin and prostaglandin activity, following restraint stress. It has been suggested that restraint stress initially activates the proposed, first mediator, prostaglandins, which in turn modulates central serotonergic activity, to induce the observed potentiation of morphine analgesia by restraint stress.
[ABSTRACT]   Full text not available  [PDF]
  1,067 83 -
RESEARCH PAPER
Behavioural interactions of metoclopramide
TJ Hemnani, PG Dashputra
April-June 1982, 14(2):183-190
Metoclopramide is devoid of significant antipsychotic action, but it may exhibit this property in combination with tolazoline, propranolol, phenobarbitone, diphenylhydantoin and mepyramine. The antipsychotic action is dose dependent on metoclopramide but the sufficient quantity of an adjuvant drug is required for triggering this action. This antipsychotic action is seen in much lower doses which do not inhibit unconditioned responses as well as forced locomotor activity. In addition metoclopramide antagonises the antipsychotic action of reserpine and haloperidol in a competitive manner, while the action of chlorpromazine is unaffected.
[ABSTRACT]   Full text not available  [PDF]
  946 103 -
ORATION
Reflections and reminiscences of a pharmacologist
MN Ghosh
April-June 1982, 14(2):135-141
Full text not available  [PDF]
  802 95 -
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