IPSIndian Journal of Pharmacology
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   1972| July-September  | Volume 4 | Issue 3  
 
 
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RESEARCH PAPER
Anticonvulsant activity of dimethindene maleate (Foristal Ciba)
Chandra Vimal
July-September 1972, 4(3):174-177
A number of antihistaminics have occasionally been tried in the treatment of epilepsy and related disorders (Douglas, 1965). Vimal chandra, Bapat and Dhawan (1969) hare reported the effectiveness of a large number of antihistaminics against Supra-maximal Electroshock Serzure Pattern test (SMES test). In our previous study we had also indicated that the anticonvulsant activity is unrelated to antihistaminic activity of this class of compounds (Vimal Chandra, Bapat and Dhawan, 1969; 1970). In the present study the anticonvulsant action of dimethindene against SMES test, Metrazole seizure threshold test (MST) and 5-HT induced convulsions was determined and compared with that of diphenylhydantoin, diphenhydramine and cyproheptadine. A preliminary report of the part of this work has already been published (Vimal Chandra. Bapat. Ansari and Janhari, 1970).
[ABSTRACT]   Full text not available  [PDF]
  3,490 226 -
SHORT COMMUNICATION
Anticholinesterase activity of Costus speciosus alkaloids
SK Bhattacharya, AK Parikh, PK Debnath, VB Pandey, NC Neogy
July-September 1972, 4(3):178-179
Full text not available  [PDF]
  2,338 398 -
RESEARCH PAPER
The effect of the Intra-uterine devices on the menstrual cycle and the duration of the period
SK Batta, B Mukerjee, G Santhakumari
July-September 1972, 4(3):170-173
Full text not available  [PDF]
  1,489 104 -
RESEARCH PAPER
Restraint stress as it influences the I131 uptake of rat thyroid and the modification by chlorpromazine
NS Pancholi, VN Sharma, P Lauria
July-September 1972, 4(3):165-169
I311 uptake was measured 4 and 24 hours after the injection of radioactive iodine in rats subjected to restraint stress for 18 hours after pretreatment with chlorpromazine (2 and 10 mg/kg) alone and in combination with restraint stress. In all these animals 1131 uptake hours, the reduction being 'more was reduced both after 4 and 24 marked after 4 hours.
[ABSTRACT]   Full text not available  [PDF]
  936 83 -
SHORT COMMUNICATION
Effect of three beta adrenergic blocking drugs on frog rectus muscle preparation
RS Gupta, NK Khanna
July-September 1972, 4(3):180-181
Full text not available  [PDF]
  908 80 -
REVIEW ARTICLE
The choice of clinical investigators
PR Imhof
July-September 1972, 4(3):182-189
Full text not available  [PDF]
  820 107 -
Factors influencing functional areas of clinical pharmacology
SM Karandikar, UK Sheth
July-September 1972, 4(3):154-164
Full text not available  [PDF]
  781 74 -
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