Indian Journal of Pharmacology Home 

EDUCATIONAL FORUM
[View FULLTEXT] [Download PDF]
Year : 2019  |  Volume : 51  |  Issue : 2  |  Page : 88--92

Wound healing effects of topical Vitamin K: A randomized controlled trial

Nader Pazyar1, Gholamreza Houshmand2, Reza Yaghoobi1, Ali Asghar Hemmati3, Zahra Zeineli4, Behnam Ghorbanzadeh5 
1 Department of Dermatology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3 Department of Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Department of Dermatology, School of Medicine; Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5 Department of Pharmacology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran

Correspondence Address:
Dr. Behnam Ghorbanzadeh
Assistant Professor in Pharmacology, School of Medicine, Dezful University of Medical Sciences, Dezful
Iran

BACKGROUND: The incidence of acute and chronic wounds has rapidly increased which treatment remains as health problem. Previously, we reported the healing effect of Vitamin K in experimental animal models. The aim of this study was to investigate the effects of topical Vitamin K on skin wound healing process in patients. MATERIALS AND METHODS: Sixty-three patients with indication for high-frequency electrocautery were enrolled in this randomized controlled trial. The patients were divided randomly into three groups. All the patients underwent high-frequency electrocautery treatment. Then, the patients in the A group received 1% Vitamin K cream, the patients in the B group received 1% phenytoin cream. Furthermore, the patients in the control group received Eucerin. The wound status (width and the time of recovery) and complications in the three groups were evaluated 2 weeks after procedure by a dermatologist. RESULTS: The effects produced by the topical Vitamin K showed a significant (P < 0.05) healing when compared with Eucerin group in parameters such as wound contraction and time to full recovery. Moreover, the healing time did not differ between phenytoin and Vitamin K groups (P = 0.16). CONCLUSION: A randomized, controlled trial suggests that topical application of Vitamin K significantly reduces healing time in patients.


How to cite this article:
Pazyar N, Houshmand G, Yaghoobi R, Hemmati AA, Zeineli Z, Ghorbanzadeh B. Wound healing effects of topical Vitamin K: A randomized controlled trial.Indian J Pharmacol 2019;51:88-92


How to cite this URL:
Pazyar N, Houshmand G, Yaghoobi R, Hemmati AA, Zeineli Z, Ghorbanzadeh B. Wound healing effects of topical Vitamin K: A randomized controlled trial. Indian J Pharmacol [serial online] 2019 [cited 2019 Jul 19 ];51:88-92
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2019;volume=51;issue=2;spage=88;epage=92;aulast=Pazyar;type=0