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Year : 2017  |  Volume : 49  |  Issue : 1  |  Page : 4--9

Is aura around citicoline fading? A systemic review

Saurabh Agarwal, Bhoomika M Patel 
 Department of Pharmacology, Nirma University, Ahmedabad, Gujarat, India

Correspondence Address:
Bhoomika M Patel
Department of Pharmacology, Nirma University, Ahmedabad, Gujarat
India

Stroke and traumatic brain injury (TBI) are the critical public health and socioeconomic problems throughout the world. At present, citicoline is used as a coadjuvant for the management of acute ischemic stroke (AIS) and TBI in various countries. This systemic review analyzes the beneficial role of citicoline in AIS and TBI. This systemic review is based on “PubMed” and “Science Direct” search results for citicoline role in stroke and TBI. In this systemic review, we included 12 human trials. A meta-analysis was performed on the basis of neurological evaluation, functional evaluation and Glasgow outcome scale, domestic adaptation evaluation outcomes, and cognitive outcome individually. In neurological evaluation, domestic adaptation evaluation, and cognitive outcomes, there was no significant difference in both the citicoline and placebo groups (odds ratio [OR] = 1.04 [0.9–1.2, P = 0.583]; OR = 1.1 [0.94–1.27, P = 0.209]; OR = 0.953 [0.75–1.2, P = 0.691]). In evaluation of functional outcomes, there was significant difference in both groups and OR was 1.18 (1.04–1.34, P = 0.01). Functional outcomes were significantly improved by citicoline, but the positive role of this drug in neurological recovery, domestic adaptation, and cognitive outcomes is still a topic of discussion for future.


How to cite this article:
Agarwal S, Patel BM. Is aura around citicoline fading? A systemic review.Indian J Pharmacol 2017;49:4-9


How to cite this URL:
Agarwal S, Patel BM. Is aura around citicoline fading? A systemic review. Indian J Pharmacol [serial online] 2017 [cited 2017 Jul 22 ];49:4-9
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2017;volume=49;issue=1;spage=4;epage=9;aulast=Agarwal;type=0