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Year : 2017  |  Volume : 49  |  Issue : 1  |  Page : 130--131

Chronic administration of phenytoin and pleomorphic adenoma: A case report and review of literature

Vikas Maharshi1, Pravesh Nagar2 
1 Department of Pharmacology, All Institute of Medical Sciences, New Delhi, India
2 Department of Pharmacology, LHMC, New Delhi, India

Correspondence Address:
Vikas Maharshi
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi
India

Adverse drug effects that are uncommon or appear only on chronic administration of a drug may not be detected in clinical trials. This explains the need of strict post-marketing vigilance on drug use. Phenytoin administration has been shown in the literature to be associated with development of neoplasia (benign/malignant). In our knowledge current work represents the first case of pleomorphic-adenoma of sub-mandibular salivary gland developed following chronic phenytoin use. A 40 year old male having a history of head trauma twenty years back, had been on tablet phenytoin 100 mg thrice daily since then. One year back he noticed a small swelling in left sub-mandibular region and gradually increasing in size. FNAC and CECT revealed the diagnosis of pleomorphic-adenoma of sub-mandibular salivary gland. Other causes were ruled out. Surgical excision was performed successfully and continuing follow-up with no recurrence at the end of 6 months. Histo-pathogical examination of the tissue did not show any malignant changes.


How to cite this article:
Maharshi V, Nagar P. Chronic administration of phenytoin and pleomorphic adenoma: A case report and review of literature.Indian J Pharmacol 2017;49:130-131


How to cite this URL:
Maharshi V, Nagar P. Chronic administration of phenytoin and pleomorphic adenoma: A case report and review of literature. Indian J Pharmacol [serial online] 2017 [cited 2019 Sep 21 ];49:130-131
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2017;volume=49;issue=1;spage=130;epage=131;aulast=Maharshi;type=0