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Year : 2016  |  Volume : 48  |  Issue : 5  |  Page : 544--549

Therapeutic insight into molsidomine, a nitric oxide donor in streptozotocin-induced diabetic nephropathy in rats

Nathani Minaz, Rema Razdan 
 Department of Pharmacology, Al-Ameen College of Pharmacy, Bengaluru - 560 027, Karnataka, India

Correspondence Address:
Nathani Minaz
Department of Pharmacology, Al-Ameen College of Pharmacy, Bengaluru - 560 027, Karnataka
India

Background: Diabetes-induced oxidative stress and hypertension play a major role in the development of nephropathy. Hence, the present study was undertaken to evaluate the protective effects of molsidomine, a nitric oxide donor in streptozotocin (STZ)-induced diabetic nephropathy (DN) in rats. Materials and Methods: Type 1 diabetes was induced through a single dose of STZ (52 mg/kg, i.p.) in male Wistar rats and then treated with molsidomine (5 and 10 mg/kg; p.o.) for 8 weeks. Physical parameters, vital and renal function test including blood glucose, albuminuria, blood urine nitrogen, serum creatinine, and kidney index were determined. Oxidative stress and lipid peroxidation were assessed in the kidney homogenate by means of antioxidant enzymes and malondialdehyde levels. Results: DN rats exhibited a significant renal dysfunction with a reduction in body weight, excessive oxidative stress, and pathological changes. Molsidomine treatment significantly improved vital sign, renal functions, and oxidative stress in DN rats in a dose-dependent manner. The protective effect of molsidomine was also substantiated by pathological changes in the architect of the kidney. Conclusion: Molsidomine shows a significant beneficial effect in Type 1 DN in rats.


How to cite this article:
Minaz N, Razdan R. Therapeutic insight into molsidomine, a nitric oxide donor in streptozotocin-induced diabetic nephropathy in rats.Indian J Pharmacol 2016;48:544-549


How to cite this URL:
Minaz N, Razdan R. Therapeutic insight into molsidomine, a nitric oxide donor in streptozotocin-induced diabetic nephropathy in rats. Indian J Pharmacol [serial online] 2016 [cited 2019 Nov 19 ];48:544-549
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2016;volume=48;issue=5;spage=544;epage=549;aulast=Minaz;type=0