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Year : 2016  |  Volume : 48  |  Issue : 4  |  Page : 462--465

Torsades de pointes induced by concomitant use of chlorpheniramine and propranolol: An unusual presentation with no QT prolongation

Altug Osken1, Nizamettin Selcuk Yelgec1, Regayip Zehir1, Tugba Kemaloglu Oz1, Selcuk Yaylaci2, Ramazan Akdemir3, Huseyin Gunduz3 
1 Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul, Turkey
2 Department of Internal Medicine, Rize Findikli Goiter Research Center, Rize, Turkey
3 Department of Cardiology, Sakarya University Faculty of Medicine, Sakarya, Turkey

Correspondence Address:
Altug Osken
Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul
Turkey

Drug-induced torsades de pointes (TdP) is a rare but potentially fatal adverse effect of commonly prescribed medications including cardiac and noncardiac drugs. Importantly, many drugs have been reported to cause the characteristic Brugada syndrome-linked electrocardiography (ECG) abnormalities and/or (fatal) ventricular tachyarrhythmias. Chlorpheniramine and propranolol have the arrhythmogenic effects reported previously. A review of literature revealed a large number of case reports of chlorpheniramine or propranolol use resulting in QTc prolongation, TdP, or both. However, we wish to report the case of a patient who was treated with a combination of chlorpheniramine and propranolol, whose ECG showed no QT prolongation but who suffered from cardiac arrest due to TdP.


How to cite this article:
Osken A, Yelgec NS, Zehir R, Oz TK, Yaylaci S, Akdemir R, Gunduz H. Torsades de pointes induced by concomitant use of chlorpheniramine and propranolol: An unusual presentation with no QT prolongation.Indian J Pharmacol 2016;48:462-465


How to cite this URL:
Osken A, Yelgec NS, Zehir R, Oz TK, Yaylaci S, Akdemir R, Gunduz H. Torsades de pointes induced by concomitant use of chlorpheniramine and propranolol: An unusual presentation with no QT prolongation. Indian J Pharmacol [serial online] 2016 [cited 2020 Jul 10 ];48:462-465
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2016;volume=48;issue=4;spage=462;epage=465;aulast=Osken;type=0