Metabolic effects as a cause of myotoxic effects of fluoroquinolones
Thomas Metterlein1, Frank Schuster2, Martin Hager2, Norbert Roewer2, Martin Anetseder3
1 Department of Anesthesiology, University Hospital Regensburg, Regensburg, Germany
2 Department of Anesthesiology, Hospital Wuerzburg, Wuerzburg, Germany
3 Department of Anesthesiology, Achdorf Hospital, Landshut, Germany
Objectives: To investigate if fluoroquinolones (FQs) influence skeletal muscle metabolism of healthy and malignant hyperthermia susceptible (MHS) pigs.
Materials and Methods: After approval from of the Animal Care Committee, 10 MHS pigs, and 6 MHS pigs were anesthetized with hemodynamic and systemic metabolic monitoring. Microdialysis catheters were placed intramuscularly. After equilibration, levofloxacin and ciprofloxacin were injected as a rapid bolus and continuous infusions. Lactate was measured in the dialysate and statistically analyzed was done (Wilcoxon-test; U-test;P < 0.05).
Results: There were no differences in age, weight, and baseline lactate levels between the groups. Both applications of levofloxacin- and ciprofloxacin-induced an increase of local lactate levels in healthy and MHS pigs. No difference between the two groups was observed.
Conclusion: FQs influence skeletal muscle metabolism. Myotoxic effects of FQs can, therefore, be explained by an influence on the cellular energy balance.
Dr. Thomas Metterlein
Department of Anesthesiology, University Hospital Regensburg, Regensburg
|How to cite this article:|
Metterlein T, Schuster F, Hager M, Roewer N, Anetseder M. Metabolic effects as a cause of myotoxic effects of fluoroquinolones.Indian J Pharmacol 2015;47:616-619
|How to cite this URL:|
Metterlein T, Schuster F, Hager M, Roewer N, Anetseder M. Metabolic effects as a cause of myotoxic effects of fluoroquinolones. Indian J Pharmacol [serial online] 2015 [cited 2020 Sep 29 ];47:616-619
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=6;spage=616;epage=619;aulast=Metterlein;type=0