Neuroprotective potential of Beta vulgaris L. in Parkinson俟Q製 disease
Vandana S Nade, Laxman A Kawale, Shankar S Zambre, Amit B Kapure
Department of Pharmacology, MVP Samaj's College of Pharmacy, Nashik, Maharashtra, India
Objective: The objective was to investigate the neuroprotective role of Beta vulgaris in Parkinson俟Q製 disease (PD).
Materials and Methods: PD was induced by administration of reserpine (5 mg/kg/day, i.p for 5 consecutive days), haloperidol (1 mg/kg, i.p.), and tacrine (2.5 mg/kg, i.p.) in experimental animals. The symptoms of PD such as tremors, akinesia, rigidity, catalepsy, and vacuous chewing movements (VCMs) were evaluated. Foot shock-induced aggression (FSIA) model was used to confirm anti-parkinsonian activity. The methanolic extract of Beta vulgaris (MEBV) was administered at doses of 100, 200, and 300 mg/kg, p.o. The combination of L-dopa and carbidopa was used as a standard drug. Behavioral studies such as locomotor activity and grip strength were determined, and oxidative stress was evaluated in FSIA model in rat brain.
Results: Pretreatment with MEBV (200 and 300 mg/kg) significantly reduced the intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, VCMs, and increase fighting behavior. The locomotor activity and grip strength were significantly increased by MEBV. In FSIA, the biochemical analysis of brain revealed the increased level of lipid peroxidation (LPO) and decreased levels of superoxide dismutase (SOD) and catalase (CAT). MEBV significantly reduced LPO level and restored the defensive antioxidant enzymes SOD and CAT in rat brain.
Conclusions: The results indicated the protective role of B. vulgaris against PD. The mechanism of protection may be due to augmentation of cellular antioxidants.
Dr. Vandana S Nade
Department of Pharmacology, MVP Samaj俟Q製 College of Pharmacy, Nashik, Maharashtra
|How to cite this article:|
Nade VS, Kawale LA, Zambre SS, Kapure AB. Neuroprotective potential of Beta vulgaris L. in Parkinson's disease.Indian J Pharmacol 2015;47:403-408
|How to cite this URL:|
Nade VS, Kawale LA, Zambre SS, Kapure AB. Neuroprotective potential of Beta vulgaris L. in Parkinson's disease. Indian J Pharmacol [serial online] 2015 [cited 2019 Oct 17 ];47:403-408
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=4;spage=403;epage=408;aulast=Nade;type=0