Indian Journal of Pharmacology Home 

RESEARCH ARTICLE
[View FULLTEXT] [Download PDF]
Year : 2014  |  Volume : 46  |  Issue : 1  |  Page : 46--50

Combination of vildagliptin and rosiglitazone ameliorates nonalcoholic fatty liver disease in C57BL/6 mice

Jeyamurugan Mookkan1, Soumita De2, Pranesha Shetty1, Nagaraj M Kulkarni1, Vijayaraj Devisingh1, Mallikarjun S Jaji1, Vinitha P Lakshmi1, Shilpee Chaudhary1, Jayanarayan Kulathingal1, Navin B Rajesh1, Shridhar Narayanan1 
1 Department of Biology, Drug Discovery Research, Orchid Chemicals and Pharmaceuticals Limited, Sozhanganallur, Chennai, Tamil Nadu, India
2 Department of Biology, Drug Discovery Research, Orchid Chemicals and Pharmaceuticals Limited, Sozhanganallur, Chennai, Tamil Nadu; Department of Pharmacology, Rolland Institute of Pharmaceutical Sciences, Berhampur, Orissa, India

Correspondence Address:
Jeyamurugan Mookkan
Department of Biology, Drug Discovery Research, Orchid Chemicals and Pharmaceuticals Limited, Sozhanganallur, Chennai, Tamil Nadu
India

Objectives: To evaluate the effect of vildagliptin alone and in combination with metformin or rosiglitazone on murine hepatic steatosis in diet-induced nonalcoholic fatty liver disease (NAFLD). Materials and Methods: Male C57BL/6 mice were fed with high fat diet (60 Kcal %) and fructose (40%) in drinking water for 60 days to induce NAFLD. After the induction period, animals were divided into different groups and treated with vildagliptin (10 mg/kg), metformin (350 mg/kg), rosiglitazone (10 mg/kg), vildagliptin (10 mg/kg) + metformin (350 mg/kg), or vildagliptin (10 mg/kg) + rosiglitazone (10 mg/kg) orally for 28 days. Following parameters were measured: body weight, food intake, plasma glucose, triglyceride (TG), total cholesterol, liver function tests, and liver TG. Liver histopathology was also examined. Results: Oral administration of vildagliptin and rosiglitazone in combination showed a significant reduction in fasting plasma glucose, hepatic steatosis, and liver TGs. While other treatments showed less or no improvement in the measured parameters. Conclusions: These preliminary results demonstrate that administration of vildagliptin in combination with rosiglitazone could be a promising therapeutic strategy for the treatment of NAFLD.


How to cite this article:
Mookkan J, De S, Shetty P, Kulkarni NM, Devisingh V, Jaji MS, Lakshmi VP, Chaudhary S, Kulathingal J, Rajesh NB, Narayanan S. Combination of vildagliptin and rosiglitazone ameliorates nonalcoholic fatty liver disease in C57BL/6 mice.Indian J Pharmacol 2014;46:46-50


How to cite this URL:
Mookkan J, De S, Shetty P, Kulkarni NM, Devisingh V, Jaji MS, Lakshmi VP, Chaudhary S, Kulathingal J, Rajesh NB, Narayanan S. Combination of vildagliptin and rosiglitazone ameliorates nonalcoholic fatty liver disease in C57BL/6 mice. Indian J Pharmacol [serial online] 2014 [cited 2020 Sep 30 ];46:46-50
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2014;volume=46;issue=1;spage=46;epage=50;aulast=Mookkan;type=0