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Year : 2013  |  Volume : 45  |  Issue : 6  |  Page : 622--624

A comparative study to evaluate efficacy, safety and cost-effectiveness between Whitfield俟Q製 ointment + oral fluconazole versus topical 1% butenafine in tinea infections of skin

Saket J Thaker1, Dimple S Mehta1, Hiral A Shah2, Jayendra N Dave2, Kunjan M Kikani3 
1 Department of Pharmacology, C.U. Shah Medical College, Surendranagar, Gujarat, India
2 Department of Dermatology Venereology and Leprology, C.U. Shah Medical College, Surendranagar, Gujarat, India
3 Department of Microbiology, C.U. Shah Medical College, Surendranagar, Gujarat, India

Correspondence Address:
Saket J Thaker
Department of Pharmacology, C.U. Shah Medical College, Surendranagar, Gujarat
India

Aims and Objectives: The aim of this study is to compare the efficacy, safety and cost-effectiveness of topical Whitfield俟Q製 ointment plus oral fluconazole with topical 1% butenafine in tinea infections of the skin. Materials and Methods: Patients were randomly allocated to the two treatment groups and advised to apply either agent topically twice-a-day for 4 weeks on the lesions and fluconazole (150 mg) was administered once a week for 4 weeks in the study group applying Whitfield俟Q製 ointment. Patients were followed-up at an interval of 10 days for clinical score and global evaluation response was assessed at baseline and during each follow-up. Results: Out of 120 patients enrolled in the study 103 completed the study. Patients treated with Whitfield俟Q製 ointment and oral fluconazole reduced mean sign and symptom score from 8.81 ± 0.82 to 0.18 ± 0.59 while butenafine treated patients reduced it from 8.88 ± 0.53 to 0.31 ± 0.67 at the end of the treatment. Nearly, 98% patients were completely cleared of the lesion on the 3 rd follow-up with both treatments. Conclusion: Whitfield俟Q製 ointment with oral fluconazole is as efficacious, safe and cost-effective as compared with 1% butenafine in tinea infections of the skin.


How to cite this article:
Thaker SJ, Mehta DS, Shah HA, Dave JN, Kikani KM. A comparative study to evaluate efficacy, safety and cost-effectiveness between Whitfield's ointment + oral fluconazole versus topical 1% butenafine in tinea infections of skin.Indian J Pharmacol 2013;45:622-624


How to cite this URL:
Thaker SJ, Mehta DS, Shah HA, Dave JN, Kikani KM. A comparative study to evaluate efficacy, safety and cost-effectiveness between Whitfield's ointment + oral fluconazole versus topical 1% butenafine in tinea infections of skin. Indian J Pharmacol [serial online] 2013 [cited 2020 Sep 29 ];45:622-624
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2013;volume=45;issue=6;spage=622;epage=624;aulast=Thaker;type=0