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Year : 2013  |  Volume : 45  |  Issue : 3  |  Page : 248--251

Anxiolytic-like effect of (4-benzylpiperazin-1-yl)(3-methoxyquinoxalin-2-yl)methanone (6g) in experimental mouse models of anxiety

Shvetank Bhatt, Radhakrishnan Mahesh, Thangaraj Devadoss, Ankur Kumar Jindal 
 Department of Pharmacy, Birla Institute of Technology & Science, Pilani, Rajasthan, India

Correspondence Address:
Shvetank Bhatt
Department of Pharmacy, Birla Institute of Technology & Science, Pilani, Rajasthan
India

Aim: The present study was designed to investigate the anxiolytic activity of 6g, a novel serotonin type-3 receptor (5-HT 3 ) receptor antagonist in experimental mouse models of anxiety. Materials and Methods: The anxiolytic activity of DQ6gDQ (1 and 2 mg/kg, intraperitoneally [i.p.]) was evaluated in mice by using a battery of behavioral tests of anxiety such as elevated plus maze (EPM), light-dark (L&D) box, hole board (HB), and open field test (OFT) with diazepam (2 mg/kg, i.p.) as standard anxiolytic. None of the tested dose of DQ6gDQ affects the base line locomotion. Results: The new chemical entity DQ6gDQ (2 mg/kg, i.p.) and diazepam (2 mg/kg, i.p.) significantly (P < 0.05) increased the percentage of time spent and number of entries in open arm in the EPM test. In the L&D test compound DQ6gDQ (2 mg/kg, i.p.) and diazepam (2 mg/kg, i.p.) significantly (P < 0.05) increased the total time spent in light compartment as well as number of transitions from one compartment to other. Compound DQ6gDQ (1 and 2 mg/kg, i.p.) and diazepam (2 mg/kg, i.p.) also significantly (P < 0.05) increased number of head dips, whereas significantly (P < 0.05) decreased the head dipping latency in HB test as compared to vehicle control group. In addition, 6g (2 mg/kg, i.p.) and diazepam (2 mg/kg, i.p.) significantly (P < 0.05) increased the ambulation scores (square crossed) in OFT and there was no significant effect of 6g (1 and 2 mg/kg, i.p.) and diazepam (2 mg/kg, i.p.) on rearing scores. Conclusion: In conclusion, these findings indicated that compound DQ6gDQ exhibited an anxiolytic-like effect in animal models of anxiety.


How to cite this article:
Bhatt S, Mahesh R, Devadoss T, Jindal AK. Anxiolytic-like effect of (4-benzylpiperazin-1-yl)(3-methoxyquinoxalin-2-yl)methanone (6g) in experimental mouse models of anxiety.Indian J Pharmacol 2013;45:248-251


How to cite this URL:
Bhatt S, Mahesh R, Devadoss T, Jindal AK. Anxiolytic-like effect of (4-benzylpiperazin-1-yl)(3-methoxyquinoxalin-2-yl)methanone (6g) in experimental mouse models of anxiety. Indian J Pharmacol [serial online] 2013 [cited 2020 Aug 10 ];45:248-251
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2013;volume=45;issue=3;spage=248;epage=251;aulast=Bhatt;type=0