Indian Journal of Pharmacology Home 

RESEARCH ARTICLE
[View FULLTEXT] [Download PDF]
Year : 2012  |  Volume : 44  |  Issue : 3  |  Page : 304--307

Alcea rosea root extract as a preventive and curative agent in ethylene glycol-induced urolithiasis in rats

Marzieh Ahmadi1, Abolfazl Khajavi Rad1, Ziba Rajaei2, Mousa-Al-Reza Hadjzadeh2, Nema Mohammadian3, Nafiseh Sadat Tabasi1 
1 Pharmacological Research Center of Medicinal Plants and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Pharmacological Research Center of Medicinal Plants and Department of Physiology, School of Medicine; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Ziba Rajaei
Pharmacological Research Center of Medicinal Plants and Department of Physiology, School of Medicine; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad
Iran

Introduction: Alcea rosea L. is used in Asian folk medicine as a remedy for a wide range of ailments. The aim of the present study was to investigate the effect of hydroalcoholic extract of Alcea rosea roots on ethylene glycol-induced kidney calculi in rats. Materials and Methods: Male Wistar rats were randomly divided into control, ethylene glycol (EG), curative and preventive groups. Control group received tap drinking water for 28 days. Ethylene glycol (EG), curative and preventive groups received 1% ethylene glycol for induction of calcium oxalate (CaOx) calculus formation; preventive and curative subjects also received the hydroalcoholic extract of Alcea rosea roots in drinking water at dose of 170 mg/kg, since day 0 or day 14, respectively. Urinary oxalate concentration was measured by spectrophotometer on days 0, 14 and 28. On day 28, the kidneys were removed and examined histopathologically under light microscopy for counting the calcium oxalate deposits in 50 microscopic fields. Results: In both preventive and curative protocols, treatment of rats with hydroalcoholic extract of Alcea rosea roots significantly reduced the number of kidney calcium oxalate deposits compared to ethylene glycol group. Administration of Alcea rosea extract also reduced the elevated urinary oxalate due to ethylene glycol. Conclusion: Alcea rosea showed a beneficial effect in preventing and eliminating calcium oxalate deposition in the rat kidney. This effect is possibly due to diuretic and anti-inflammatory effects or presence of mucilaginous polysaccharides in the plant. It may also be related to lowering of urinary concentration of stone-forming constituents.


How to cite this article:
Ahmadi M, Rad AK, Rajaei Z, Hadjzadeh MA, Mohammadian N, Tabasi NS. Alcea rosea root extract as a preventive and curative agent in ethylene glycol-induced urolithiasis in rats.Indian J Pharmacol 2012;44:304-307


How to cite this URL:
Ahmadi M, Rad AK, Rajaei Z, Hadjzadeh MA, Mohammadian N, Tabasi NS. Alcea rosea root extract as a preventive and curative agent in ethylene glycol-induced urolithiasis in rats. Indian J Pharmacol [serial online] 2012 [cited 2017 Nov 23 ];44:304-307
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2012;volume=44;issue=3;spage=304;epage=307;aulast=Ahmadi;type=0