Reproductive toxicity of sodium valproate in male rats
Laxminarayana Bairy1, Vijay Paul2, Yeshwanth Rao3
1 Department of Pharmacology, Kasturba Medical College, Manipal, India
2 Department of Anatomy, Maleka Manipal Medical College, Manipal, India
3 Department of Pharmacology, Maleka Manipal Medical College, Manipal, India
Objectives: To assess the effects of sodium valproate on rat sperm morphology, sperm count, motility, and histopathological changes in testis.
Materials and Methods: Male Wistar rats (12 week old) were treated with sodium valpraote and sacrificed at the end of 2 nd , 4 th , 5 th , 7 th , 10 th and 15 th week after the last exposure to sodium valproate. Epididymal sperm count, sperm motility, sperm morphology, and histopathology of testes were analyzed.
Results: Sperm count and sperm motility were decreased significantly by sodium valproate. The percentage of abnormal sperms increased in a dose-dependent manner. A histopathological study revealed that sodium valproate had caused sloughing of epithelial cells in testes.
Conclusion: Sodium valproate causes reversible change in sperm motility, sperm count, morphology, and cytoarchitecture of testes.
Department of Pharmacology, Kasturba Medical College, Manipal
|How to cite this article:|
Bairy L, Paul V, Rao Y. Reproductive toxicity of sodium valproate in male rats.Indian J Pharmacol 2010;42:90-94
|How to cite this URL:|
Bairy L, Paul V, Rao Y. Reproductive toxicity of sodium valproate in male rats. Indian J Pharmacol [serial online] 2010 [cited 2019 Oct 18 ];42:90-94
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2010;volume=42;issue=2;spage=90;epage=94;aulast=Bairy;type=0