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Year : 2008  |  Volume : 40  |  Issue : 6  |  Page : 248--250

The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats

P Vijay1, R Yeshwanth2, KL Bairy3 
1 Department of Anatomy, Maleka Manipal Medical College, Manipal, India
2 Department of Pharmacology, Maleka Manipal Medical College, Manipal, India
3 Department of Pharmacology, Kasturba Medical College, Manipal, India

Correspondence Address:
K L Bairy
Department of Pharmacology, Kasturba Medical College, Manipal
India

Objective: To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats. Methods: Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2 nd , 4 th , 5 th , 7 th , 10 th and 15 th week, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis. Results: The intratesticular testosterone level was significantly (P<0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P<0.001) increased by valproate in a time dependent manner. Conclusion: Valproate causes reversible change in intratesticular testosterone and LDH level.


How to cite this article:
Vijay P, Yeshwanth R, Bairy K L. The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats.Indian J Pharmacol 2008;40:248-250


How to cite this URL:
Vijay P, Yeshwanth R, Bairy K L. The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats. Indian J Pharmacol [serial online] 2008 [cited 2020 Sep 28 ];40:248-250
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2008;volume=40;issue=6;spage=248;epage=250;aulast=Vijay;type=0