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Year : 2007  |  Volume : 39  |  Issue : 1  |  Page : 5--14

Monoclonal antibodies: Pharmacological relevance

Jasleen Kaur, DK Badyal, PP Khosla 
 Department of Pharmacology, Christian Medical College and Hospital, Ludhiana, India

Correspondence Address:
Jasleen Kaur
Department of Pharmacology, Christian Medical College and Hospital, Ludhiana
India

Monoclonal antibodies (MAbs), a new class of biological agents, are used these days in therapeutics and diagnosis. MAbs also labeled as «SQ»magic bullets«SQ», are highly specific antibodies produced by a clone of single hybrid cells formed in the laboratory by fusion of B cell with the tumor cell. The hybridoma formed yields higher amount of MAbs. MAbs can be produced in vitro and in vivo . Animals are utilized to produce MAbs, but these antibodies are associated with immunogenic and ethical problems. Of late, recombinant DNA technology, genetic engineering,phage display and transgenic animals are used to produce humanized MAbs or pure human MAbs, which have fewer adverse effects. MAbs alone or conjugated with drugs, toxins, or radioactive atoms are used for treatment of cancer, autoimmune disorders, graft rejections, infectious diseases, asthma, and various cardiovascular disorders. New MAbs are being developed which are more specific and less toxic.


How to cite this article:
Kaur J, Badyal D K, Khosla P P. Monoclonal antibodies: Pharmacological relevance.Indian J Pharmacol 2007;39:5-14


How to cite this URL:
Kaur J, Badyal D K, Khosla P P. Monoclonal antibodies: Pharmacological relevance. Indian J Pharmacol [serial online] 2007 [cited 2020 Aug 4 ];39:5-14
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2007;volume=39;issue=1;spage=5;epage=14;aulast=Kaur;type=0