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Year : 2005  |  Volume : 37  |  Issue : 3  |  Page : 141--147

Curcumin: A natural antiinflammatory agent

K Kohli, J Ali, MJ Ansari, Z Raheman 
 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard University, Hamdard Nagar, New Delhi, India

Correspondence Address:
K Kohli
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard University, Hamdard Nagar, New Delhi
India

Extensive scientific research on curcumin, a natural compound present in the rhizomes of plant Curcuma longa Linn., demonstrated its antiinflammatory action. Curcumin was found to inhibit arachidonic acid metabolism, cyclooxygenase, lipoxygenase, cytokines (Interleukins and tumour necrosis factor) Nuclear factor-kB and release of steroidal hormones. Curcumin was reported to stabilize lysosomal membrane and cause uncoupling of oxidative phosphorylation besides having strong oxygen radical scavenging activity, which was responsible for its antiinflammatory property. In various animal studies, a dose range of 100-200 mg/kg body weight exhibited good antiinflammatory activity and seemed to have negligible adverse effect on human systems. Oral LD50 in mice was found to be more than 2.0 g/kg body weight.


How to cite this article:
Kohli K, Ali J, Ansari M J, Raheman Z. Curcumin: A natural antiinflammatory agent.Indian J Pharmacol 2005;37:141-147


How to cite this URL:
Kohli K, Ali J, Ansari M J, Raheman Z. Curcumin: A natural antiinflammatory agent. Indian J Pharmacol [serial online] 2005 [cited 2019 Nov 17 ];37:141-147
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2005;volume=37;issue=3;spage=141;epage=147;aulast=Kohli;type=0