Effect of shilajit on blood glucose and lipid profile in alloxan-induced diabetic rats
NA Trivedi, B Mazumdar, JD Bhatt, KG Hemavathi
Department of Pharmacology, Medical College, Baroda - 390 001, India
OBJECTIVE: To study the effect of shilajit (a herbomineral preparation) on blood glucose and lipid profile in euglycemic and alloxan-induced diabetic rats and its effects on the above parameters in combination with conventional antidiabetic drugs.
MATERIAL AND METHODS: Diabetes was induced in albino rats by administration of a single dose of alloxan monohydrate 5% (125 mg/kg, i.p.). Effects of three different doses of shilajit (50, 100 and 200 mg/kg/day, orally), alone for 4 weeks and a combination of shilajit (100 mg/kg/day, orally) with either glibenclamide (5 mg/kg/day, orally) or metformin (0.5 g/kg/day, orally) for 4 weeks were studied on blood glucose and lipid profile.
RESULTS: In the diabetic rats, all the three doses of shilajit produced a significant reduction in blood glucose levels and also produced beneficial effects on the lipid profile. The maximum effect was observed with the 100 mg/kg/day dose of shilajit. Combination of shilajit (100 mg/kg) with glibenclamide (5 mg/kg/day) or metformin (0.5 gm/kg/day) significantly enhanced the glucose-lowering ability and improvement in lipid profile than any of these drugs given alone.
CONCLUSION: Shilajit is effective in controlling blood glucose levels and improves the lipid profile.
N A Trivedi
Department of Pharmacology, Medical College, Baroda - 390 001
|How to cite this article:|
Trivedi N A, Mazumdar B, Bhatt J D, Hemavathi K G. Effect of shilajit on blood glucose and lipid profile in alloxan-induced diabetic rats.Indian J Pharmacol 2004;36:373-376
|How to cite this URL:|
Trivedi N A, Mazumdar B, Bhatt J D, Hemavathi K G. Effect of shilajit on blood glucose and lipid profile in alloxan-induced diabetic rats. Indian J Pharmacol [serial online] 2004 [cited 2019 Nov 20 ];36:373-376
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2004;volume=36;issue=6;spage=373;epage=376;aulast=Trivedi;type=0