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Year : 2004  |  Volume : 36  |  Issue : 1  |  Page : 10--14

Antitnf-a strategy: Present status of this therapeutic paradigm

J Singh, A Suruchi 
 Department of Pharmacology, PGIMS, Rohtak - 124001, Haryana, India

Correspondence Address:
J Singh
Department of Pharmacology, PGIMS, Rohtak - 124001, Haryana
India

Tumor necrosis factor-alpha (TNF-a), a proinflammatory cytokine is involved in the pathophysiology of a number of disorders including Crohn’s disease, rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. AntiTNF-a strategies target this pathogenic element to provide clinical benefit. The various strategies are in preliminary stage of experimentation and much remains to be elucidated before these are applied clinically. Though antiTNF-a therapy is currently approved only for rheumatoid arthritis and Crohn’s disease, the future of this therapeutic paradigm holds much promise. The number of official indications for strategies against this biologic agent are likely to increase to include congestive heart failure, psoriasis, asthma, septic shock, stroke and malignancy. This will make it a truly broad spectrum therapeutic weapon currently available to us.


How to cite this article:
Singh J, Suruchi A. Antitnf-a strategy: Present status of this therapeutic paradigm.Indian J Pharmacol 2004;36:10-14


How to cite this URL:
Singh J, Suruchi A. Antitnf-a strategy: Present status of this therapeutic paradigm. Indian J Pharmacol [serial online] 2004 [cited 2020 Feb 26 ];36:10-14
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2004;volume=36;issue=1;spage=10;epage=14;aulast=Singh;type=0