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Year : 2000  |  Volume : 32  |  Issue : 3  |  Page : 226--230

Central nitrinergic system in Brewer s yeast induced peripheral inflammation in rats

J Sarma1, SK Tandan2, SW Hajare3, D Kumar4, V Raviprakash5 
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Correspondence Address:
J Sarma


Objective: To investigate the role of central nitrinergic system in Brewer«SQ»s yeast induced peripheral inflammation in rats. Methods: Permanent icv cannulation in rats was performed stereotaxically into the right lateral ventricle under ketamine hydrochloride anaesthesia. NO modulators viz NO synthase inhibitors, NO precursor, NO donors and NO scavengers were administered icv 30 min prior to induction of paw oedema by injecting 0.1 ml of 20% (W/V) Brewer«SQ»s yeast below the planter aponeurosis of hind paw in rats. Paw volume up to the ankle joint was recorded plethysmographically. Results: NO synthase inhibitors and NO scavenger haemoglobin (Hb) were found to be potent inhibitors of paw volume increase in the late phase (1-5 h) than early period (15-60 min). NO donors SIN-1, SNP and NO precursor L-arginine were found to increase the oedema volume. D- arginine and methylene blue were without any effect. Conclusion: Central nitrinergic system modulates the Brewer«SQ»s yeast induced peripheral inflammation in rats. Both endogenous and exogenous NO are involved in the inflammatory process.


How to cite this article:
Sarma J, Tandan S K, Hajare S W, Kumar D, Raviprakash V. Central nitrinergic system in Brewer s yeast induced peripheral inflammation in rats.Indian J Pharmacol 2000;32:226-230


How to cite this URL:
Sarma J, Tandan S K, Hajare S W, Kumar D, Raviprakash V. Central nitrinergic system in Brewer s yeast induced peripheral inflammation in rats. Indian J Pharmacol [serial online] 2000 [cited 2020 Apr 1 ];32:226-230
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2000;volume=32;issue=3;spage=226;epage=230;aulast=Sarma;type=0