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Year : 2000  |  Volume : 32  |  Issue : 3  |  Page : 202--205

Cardioprotective actions of enalapril and lisinopril on ischemia-reperfusion induced myocardial infarction in normal and salt loaded rats

A Annapurna1, Babu M Rajendra2, D Ranganayakulu3 
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A Annapurna


Objective: To evaluate the cardioprotective actions of two angiotensin converting enzyme (ACE) inhibitors, enalapril and lisinopril on myocardial infarction in normal and salt loaded rats. Methods: Myocardial infarction was produced by occlusion of left coronary artery for 30 minutes followed by 4 hours of reperfusion. Infarct size was measured by using triphenyl tetrazolium chloride (TTC) stain method. Results: Infarct size, expressed as percent myocardial infarction (PMI) was found to be 34.84 with untreated control animals, whereas PMI was significantly reduced to 14.78 and 13.54 with enalapril (3 mg/kg) and lisinopril (3 mg/kg) pretreatment respectively. In salt loaded animal groups, PMI was found to be 37.20 with control untreated and reduced to 13.41 with enalapril pretreatment (3 mg/kg) and 13.19 with lisinopril pretreatment (3 mg/kg) respectively. Conclusion: The results suggest a possible cardioprotective role for ACE inhibitors.


How to cite this article:
Annapurna A, Rajendra BM, Ranganayakulu D. Cardioprotective actions of enalapril and lisinopril on ischemia-reperfusion induced myocardial infarction in normal and salt loaded rats.Indian J Pharmacol 2000;32:202-205


How to cite this URL:
Annapurna A, Rajendra BM, Ranganayakulu D. Cardioprotective actions of enalapril and lisinopril on ischemia-reperfusion induced myocardial infarction in normal and salt loaded rats. Indian J Pharmacol [serial online] 2000 [cited 2020 Apr 2 ];32:202-205
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2000;volume=32;issue=3;spage=202;epage=205;aulast=Annapurna;type=0