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Year : 2000  |  Volume : 32  |  Issue : 2  |  Page : 126--128

Involvement of NMDA-nitric oxide pathway in the facilitatory effect of morphine in hypoxia-induced lethality in mice

I Dokmeci1, A Ulugol2, A Tuncer3, T Dost4, D Dokmeci5, H Karadag6 
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Correspondence Address:
I Dokmeci


Objective: The contribution of N-methyl-D-aspartate (NMDA) receptors and nitric oxide (NO) to the effect of morphine on hypoxia-induced lethality was investigated in the present experiments. Methods: Mice were subjected to hypoxia by putting them in a tightly closed glass container. The latencies for death were recorded. Results: MK-801 (0.25 mg/kg, i.p.) and N(-nitro-L-arginine-methyl ester (L-NAME, 10 mg/kg, i.p.), at doses which themselves produced no effect on hypoxia-induced lethality, attenuated the hypoxic effect of morphine (10 mg/kg, i.p.) significantly, but not completely. Concomitant administrations of NMDA (10 mg/ kg) or L-arginine (500 mg/kg, i.p.), completely reversed the protective effects of MK-801 and L-NAME, indicating the possible involvement of NO-linked NMDA receptors in the hypoxic effect of morphine. Conclusion: Hypoxia induced lethality may be, at least partly, mediated through the NMDA-NO pathway.


How to cite this article:
Dokmeci I, Ulugol A, Tuncer A, Dost T, Dokmeci D, Karadag H. Involvement of NMDA-nitric oxide pathway in the facilitatory effect of morphine in hypoxia-induced lethality in mice.Indian J Pharmacol 2000;32:126-128


How to cite this URL:
Dokmeci I, Ulugol A, Tuncer A, Dost T, Dokmeci D, Karadag H. Involvement of NMDA-nitric oxide pathway in the facilitatory effect of morphine in hypoxia-induced lethality in mice. Indian J Pharmacol [serial online] 2000 [cited 2020 Aug 10 ];32:126-128
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=2000;volume=32;issue=2;spage=126;epage=128;aulast=Dokmeci;type=0