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Year : 1999  |  Volume : 31  |  Issue : 3  |  Page : 195--199

Effect of dietary calcium, lisinopril and insulin on diabetic hypertensive animals

MM Shah1, CD Upasani2, R Bharatrajan3, R Balaraman4, SP Rathod5 
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Correspondence Address:
M M Shah


Objectives: To compare the effect of calcium enriched diet (2% CED, 8 weeks), lisinopril (5 mg/kg/day, p.o., 2 weeks) and insulin (1 U/kg/day, s.c., 2 weeks) on blood pressure and vascular reactivity of diabetic rats and diabetic hypertensive rats. Methods: In the first set of experiments, blood pressure and vascular reactivity of diabetic rats (alloxan, 150 mg/kg, i.p., single dose) was compared with that of diabetic rats treated with CED, lisinopril and insulin. In the second set of experiments, blood pressure and vascular reactivity of diabetic hypertensive rats (unilateral nephrectomy followed by DOCA, 25 mg/kg/week, s.c., 5 weeks) was compared with that of diabetic hypertensive rats treated with CED, lisinopril and insulin. Results: Administration of CED and lisinopril significantly reduced the blood pressure and vascular reactivity in diabetic as well as diabetic hypertensive rats whereas insulin reduced these significantly only in the diabetic rats. Conclusion: CED and lisinopril exhibited significant antihypertensive effect in the diabetic hypertensive model.


How to cite this article:
Shah M M, Upasani C D, Bharatrajan R, Balaraman R, Rathod S P. Effect of dietary calcium, lisinopril and insulin on diabetic hypertensive animals.Indian J Pharmacol 1999;31:195-199


How to cite this URL:
Shah M M, Upasani C D, Bharatrajan R, Balaraman R, Rathod S P. Effect of dietary calcium, lisinopril and insulin on diabetic hypertensive animals. Indian J Pharmacol [serial online] 1999 [cited 2020 Aug 15 ];31:195-199
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1999;volume=31;issue=3;spage=195;epage=199;aulast=Shah;type=0