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|Year : 1999 | Volume
| Issue : 3 | Page : 187--189
Effect of calcium channel blockers on aluminium treated rat brain serine/threonine phosphoprotein phosphatase 2B
Basu Srabanti1, Nag Chaudhuri Aditi2
Objectives: To examine the effect of aluminium (Al) on different types of phosphatases in rat brain in the presence and absence of Ca 2+ channel blockers.
Methods: Phosphoprotein phosphatase activities were measured in brains of male Sprague Dawley rats treated with aluminium chloride (AlCl3 ) , Ca2+ channel blockers per se and AlCl3 with Ca2+ channel blockers for 40 days using standard techniques.
Results: Tyrosine phosphoprotein phosphatase (TPP) activity, activation of TPP by EDTA and activity of serine/threonine phosphoprotein phosphatase 2B (PP2B) were decreased by Al. Nifedipine treated rats regained the activities of TPP and PP2B and showed increased activity of serine/threonine phosphatase 2C (PP2C). Verapamil and diltiazem were ineffective in restoring the normal activities of the enzymes.
Conclusion: The restoration of the activity of PP2B by nifedipine indicates that there may be a competition between Al and Ca and between Al and Ca2+ channel blocker nifedipine. Hence the
Ca 2+ channel blocker nifedipine can be used to prevent Al 3+ toxicity.
|How to cite this article:|
Srabanti B, Aditi NC. Effect of calcium channel blockers on aluminium treated rat brain serine/threonine phosphoprotein phosphatase 2B.Indian J Pharmacol 1999;31:187-189
|How to cite this URL:|
Srabanti B, Aditi NC. Effect of calcium channel blockers on aluminium treated rat brain serine/threonine phosphoprotein phosphatase 2B. Indian J Pharmacol [serial online] 1999 [cited 2020 Sep 21 ];31:187-189
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1999;volume=31;issue=3;spage=187;epage=189;aulast=Srabanti;type=0