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Year : 1998  |  Volume : 30  |  Issue : 3  |  Page : 186--190

The relation between centrally situated noradrenergic, adenosine-A, and GABA, receptors while inhibiting gastric acid secretion in pylorus ligated conscious rats

PR Thakur1, SN Umathe2 
1 
2 

Correspondence Address:
P R Thakur


Objectives: To evaluate the relationship between centrally situated noradrenergic, adenosine-A, and GABAB receptors particularly because activation of each of them is known to inhibit gastric acid secretion. Methods: The total gastric acid output over a period of 4 h was investigated in pylorus ligated conscious rats who had received following i.c.v. treatments through a chronically implanted screw cannula in skull. In the first set of experiments rats were treated with an agonist i.e. either noradrenaline (NA,1 ęg/rat) or balcofen (5ęg/rat) or (-) N6 phenyl isopropyladenosine (L-PIA,10 ęg/rat) just after the pylorus ligation. In the second set of experiments the rats received either prazosin ((-adrenergic blocker, 5 ęg/rat) or 8 phenyltheophylline (8-PT, adenosine A, antagonist, 50ęg/rat) or phaclofen (GABAB antagonist, 5 ęg/ rat) 20 minutes prior to the administration of either NA (1 ęg/rat) or baclofen (5 ęg/rat) or L-PIA (10 ęg/rat). Results : The i.c.v. administration of NA, L-PIA and baclofen significantly inhibited gastric acid output in pylorus ligated conscious rats. Prior treatment of rats with prazosin attenuated the antisecretory effect of NA as well as L-PIA, whereas the effect of baclofen remained unaffected. 8-PT and phaclofen, however, could only attenuate the antisecretory effect of L-PIA and baclofen respectively. Conclusion: The centrally situated adenosine-A, receptors operate through (-adrenergic receptors while inhibiting gastric acid secretion. The activation of centrally situated phaclofen sensitive GABAB receptors independently inhibit acid secretion and does not bear any relation with centrally situated (-adrenergic or adenosine-A, receptors.


How to cite this article:
Thakur P R, Umathe S N. The relation between centrally situated noradrenergic, adenosine-A, and GABA, receptors while inhibiting gastric acid secretion in pylorus ligated conscious rats.Indian J Pharmacol 1998;30:186-190


How to cite this URL:
Thakur P R, Umathe S N. The relation between centrally situated noradrenergic, adenosine-A, and GABA, receptors while inhibiting gastric acid secretion in pylorus ligated conscious rats. Indian J Pharmacol [serial online] 1998 [cited 2020 Jul 3 ];30:186-190
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1998;volume=30;issue=3;spage=186;epage=190;aulast=Thakur;type=0