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Year : 1997  |  Volume : 29  |  Issue : 4  |  Page : 244--249

Enhancement of the cytotoxic effects of echitamine chloride by vitamin A: An in vitro study on Ehrlich ascites carcinoma cell culture

Viswanathan Saraswathi1, Ramamurthy Nalini2, S Subramanian3, V Mathuram4, S Govindasamy5 
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Correspondence Address:
Viswanathan Saraswathi


Objectives: A study was conducted to examine the in vitro cytotoxic effects of Echitamine chloride (EC), a plant alkaloid extracted from the bark of Alstonia scholaris. Since vitamin A was found to enhance the anticancer effects of several anticancer drugs, the synergistic effects of these two drugs were also studied. Methods: Echitamine chloride at a concentration of 200śM and Vitamin A at a concentration of 10 śM were added alone as well as in combination to the Ehrlich Ascites Carcinoma (EAC) cell cultures. Cell viability, antioxidant enzyme status, lipid peroxidation and 3H -Thymidine incorporation were studied. Results: The cultures treated with EC and vitamin A combination showed significant cytotoxic effect than the cultures treated with individual drugs. Conclusion: It may be concluded that EC in combination with vitamin A has an enhanced cytotoxic effect on Ehrlich Ascites Carcinoma cell culture.


How to cite this article:
Saraswathi V, Nalini R, Subramanian S, Mathuram V, Govindasamy S. Enhancement of the cytotoxic effects of echitamine chloride by vitamin A: An in vitro study on Ehrlich ascites carcinoma cell culture.Indian J Pharmacol 1997;29:244-249


How to cite this URL:
Saraswathi V, Nalini R, Subramanian S, Mathuram V, Govindasamy S. Enhancement of the cytotoxic effects of echitamine chloride by vitamin A: An in vitro study on Ehrlich ascites carcinoma cell culture. Indian J Pharmacol [serial online] 1997 [cited 2020 Mar 30 ];29:244-249
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1997;volume=29;issue=4;spage=244;epage=249;aulast=Saraswathi;type=0