Indian Journal of Pharmacology Home 

RESEARCH PAPER
[Download PDF]
Year : 1997  |  Volume : 29  |  Issue : 4  |  Page : 222--227

Further studies on the antihepatotoxic activity of jigrine

N Karunakar1, KK Pillai2, SZ Hussain3, M Rao4, DK Balani5, M Imran6 
1 
2 
3 
4 
5 
6 

Correspondence Address:
N Karunakar


Objectives: To evaluate the anti-hepatotoxic activity of Jigrine (a Unani polypharmaceutical herbal formulation) against alcohol and CCl4 induced hepatotoxicity in rats. Methods: Albino rats (Wistar strain) were given alcohol (40% alcohol, 2.0ml/100g, po for 21 days) and CCl4 (1:1 in groundnut oil, 0.1ml/kg, SC on 20th day) to induce hepatotoxicity. Jigrine at two dose levels (0.5ml and 1.0ml/kg, po) was given for a period of 7 days (i.e. 15th to 21st day) to the rats treated with alcohol and CCl4. Silymarin (25mg/kg, po) was given as a reference drug. Biochemical parameters like serum AST, ALT, tissue (-GTP, triglycerides and lipid peroxides were estimated to assess the liver function. Histopathological studies were also done to confirm the biochemical changes, Results: The mean SEM serum AST, ALT levels in control animals were 44.4 5.7 Units/ml and 55.2 7.9 Units/ml, where as in alcohol - CCl4 treated rats the levels rose to 234 4.6 Units/ml and 122.4 21.9 Units/ml. Jigrine at two dose levels reduced the AST and ALT levels to 190.8 7.6 Units/ml; 87.2 15.6 Units/ml and 160.4 9.9 Units/ml; 68.8 6.4 Units/ml. Silymarin reduced AST and ALT levels to 136 13.4 Units/ml and 64 5.3 Units/ml. The tissue mean SEM of ( -GTP, triglycerides and TBARS in control animals were 40.9 3.2 I.U; 26.5 4.5 mg/100ml and 1.44 0.2 n.mole MDA/mg protein, where as in alcohol -CCl4 treated rats the levels rose to 122.25 5.3 I.U; 174 12.6 mg/100ml and 7.65 0.7 n.mole MDA/mg protein. Jigrine (0.5ml/kg, po) reduced the ( -GTP to 84.13 7.2 I.U; triglycerides to 118.5 12.8 mg/100ml and TBARS to 3.69 0.6 n.mole MDA/mg protein. Jigrine (1ml/kg, po) reduced the y GTP to 69.07 13.1 I.U; triglycerides to 84 14.8 mg/100ml and TBARS to 1.81 0.17 n.mole MDA/mg protein. Silymarin (25mg/kg, po) reduced the ( -GTP to 64.5 12.4 I.U; triglycerides to 60 9.1 mg/100ml and TBARS to 2.33 0.2 n.mole MDA/mg protein. Conclusion: The study confirms the antihepatotoxic activity of Jigrine which may be attributed to the membrane stabilizing and antioxidant property of this medicine.


How to cite this article:
Karunakar N, Pillai K K, Hussain S Z, Rao M, Balani D K, Imran M. Further studies on the antihepatotoxic activity of jigrine.Indian J Pharmacol 1997;29:222-227


How to cite this URL:
Karunakar N, Pillai K K, Hussain S Z, Rao M, Balani D K, Imran M. Further studies on the antihepatotoxic activity of jigrine. Indian J Pharmacol [serial online] 1997 [cited 2020 Mar 29 ];29:222-227
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1997;volume=29;issue=4;spage=222;epage=227;aulast=Karunakar;type=0