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Year : 1997  |  Volume : 29  |  Issue : 3  |  Page : 194--197

The anticonvulsant effect of pentazocine against maximal electroshock seizure in mice

Manocha Anshu1, KK Sharma2, PK Mediratta3 
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2 
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Correspondence Address:
Manocha Anshu


Objectives: The present study was designed to investigate whether pentazocine protects against electrically-Induced seizures in mice. An attempt was also made to determine the possible opioid receptor mechanism involved. Methods: Maximal electroshock (MES) seizures were induced in mice via transauricular electrodes (60 mA, 0.2 sec). Seizure severity was assessed by the duration of hindlimb extensor phase. Results: lntraperitoneal administration of pentazocine resulted in a dose dependent inhibition of the hind-limb extensor phase during the MES. The ED50for the effect was found to be 15 mg/kg. The anticonvulsant effect of pentazocine was completely antagonized by the high doses (1.O mg/kg, 5.0/kg), but not by the low doses (0.1 mg/kg, 0.25mg/kg) of i.p. naloxone. Conclusion: The results suggest that the anti-MES effect of pentazocine is mediated by k-receptors, since naloxone in high doses is known to block these receptors.


How to cite this article:
Anshu M, Sharma K K, Mediratta P K. The anticonvulsant effect of pentazocine against maximal electroshock seizure in mice.Indian J Pharmacol 1997;29:194-197


How to cite this URL:
Anshu M, Sharma K K, Mediratta P K. The anticonvulsant effect of pentazocine against maximal electroshock seizure in mice. Indian J Pharmacol [serial online] 1997 [cited 2020 Apr 3 ];29:194-197
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1997;volume=29;issue=3;spage=194;epage=197;aulast=Anshu;type=0