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Year : 1995  |  Volume : 27  |  Issue : 3  |  Page : 152--155

Study of the effect of steroid hormones on serum high- and low-molecular weight alkaline phosphatase

AA Moshtaghie1, M Ani2, M Soltani3 
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A A Moshtaghie


The present study was undertaken to investigate the effects of testosterone, 17-( - estradiol and castration on serum alkaline phosphatase isoenzymes in male rats. Daily administration of testosterone (2 mg/kg) for 15, 30 and 60 days increased serum total alkaline phosphatase activity by 9, 26 and 65 percent respectively. Estradiol administration (0.2 mg/kg) in the same periods led to the increase of 69, 67 and 68 percent. Enzyme fractionation on sephacryl S-300 revealed that the increase in alkaline phosphatase activity was due to the absolute elevation of low-molecular weight alkaline phosphatase isoenzyme. Castration or treatment with actinomvcin-D puromvcin of the animal diminished enzyme activity bv 28-37 percent. The estradiol induced increase in enzymeactivity had additive effect with puromycin or actinomycin D in the doses used.


How to cite this article:
Moshtaghie A A, Ani M, Soltani M. Study of the effect of steroid hormones on serum high- and low-molecular weight alkaline phosphatase.Indian J Pharmacol 1995;27:152-155


How to cite this URL:
Moshtaghie A A, Ani M, Soltani M. Study of the effect of steroid hormones on serum high- and low-molecular weight alkaline phosphatase. Indian J Pharmacol [serial online] 1995 [cited 2020 Aug 12 ];27:152-155
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1995;volume=27;issue=3;spage=152;epage=155;aulast=Moshtaghie;type=0