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Year : 1994  |  Volume : 26  |  Issue : 4  |  Page : 266--269

Studies on the antiproliferative effect of some naturally occurring bioflavonoidal compounds against human carcinoma of larynx and Sarcoma-180 cell lines

V Elangovan1, Ramamoorthy Nalini2, S Balasubramanian3, N Sekar4, S Govindasamy5 
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Correspondence Address:
V Elangovan


In vitro effects of bioflavonoids namely quercetin, (+) catechin, luteolin and rutin against human carcinoma of larynx (HEp-2) and sarcoma-l 80 (S-l 80) cell lines were studied. It was observed that the flavonoid luteolin inhibited the proliferation of these cells and the inhibiiory concentration (IC50) was found to be 21 (g/ml which was closely equal to plumbagin (10( g), an anticancer drug. At 28 (g/ml concentration, quercetin showed 50% cell death in HEp-2 cells and in S-l 80, the inhibition was less. Depletion of glutathione in the cells coupled with loss of cell viability was observed in the luteolin treated cultures. Further, [3H] thymidine uptake studies revealed a decline in DNA synthesis in the presence of luteolin.


How to cite this article:
Elangovan V, Nalini R, Balasubramanian S, Sekar N, Govindasamy S. Studies on the antiproliferative effect of some naturally occurring bioflavonoidal compounds against human carcinoma of larynx and Sarcoma-180 cell lines.Indian J Pharmacol 1994;26:266-269


How to cite this URL:
Elangovan V, Nalini R, Balasubramanian S, Sekar N, Govindasamy S. Studies on the antiproliferative effect of some naturally occurring bioflavonoidal compounds against human carcinoma of larynx and Sarcoma-180 cell lines. Indian J Pharmacol [serial online] 1994 [cited 2020 May 27 ];26:266-269
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=4;spage=266;epage=269;aulast=Elangovan;type=0