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Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 218--221

The effect of adrenal steroids on imipramine analgesia

SN Mandhane1, CT Chopde2, AV Muthal3 
1 
2 
3 

Correspondence Address:
S N Mandhane


The effect of adrenocorticosteroids on imioramine (IMA) analgesia was evaluated in sham-adrenalectomised (sham-ADX) and adrknalectomised (ADX) rats using tail-flick test. Adrenalectomised rats displayed greater sensitivityto IMA(5-20 mg/kg, i.p.) induced analgesia. Subcutaneous administration of glucocorticoids,. corticosterone -(0.01-10 mg/kg), hydrocortisone (0.5 mg/kg), dexamethasone (0.5 mg/kg), attenuated the analgesic effect of IMA (20 mg/kg) in sham-ADX or ADX rats. Mineralocorticoid, aldosterone (0.5-10 mg/kg), had no effect, Adrenalectomy per se or adrenocorticosteroids per se did not alter the basal tail-flick reaction latency. Thus the enhanced potency of IMA in ADX rats may be mediated by the absence of circulating adrenocorticosteroids.


How to cite this article:
Mandhane S N, Chopde C T, Muthal A V. The effect of adrenal steroids on imipramine analgesia.Indian J Pharmacol 1994;26:218-221


How to cite this URL:
Mandhane S N, Chopde C T, Muthal A V. The effect of adrenal steroids on imipramine analgesia. Indian J Pharmacol [serial online] 1994 [cited 2020 May 29 ];26:218-221
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=3;spage=218;epage=221;aulast=Mandhane;type=0