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Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 209--212

Time dependent preventive effects of simultaneous administration of selenium or zinc during mercury exposure in rats

GJS Flora1, R Mathur2, Sandhu Neelu3, KK Dua4 
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Correspondence Address:
GJS Flora


Time dependent protective effects of selenium or zincsupplementation during mercury exposure was investigated in female rats. Concomitant exposure to selenium or zinc during 3 days of mercury administration prevented most of the mercury induced clinical and biochemical indices of renal toxicity. Mercury contents of kidneys were also less marked in animals administered mercury and selenium as observed on day 4. However, it increased significantly in blood while, remained unchanged in hepatic tissue. Following cessation of selenium supplementation, toxic effects of mercury reappeared on day 8. The results suggest that selenium administration reduces the renal toxicity of mercury. Zinc seems to have no preventive value against mercury.


How to cite this article:
Flora G, Mathur R, Neelu S, Dua K K. Time dependent preventive effects of simultaneous administration of selenium or zinc during mercury exposure in rats.Indian J Pharmacol 1994;26:209-212


How to cite this URL:
Flora G, Mathur R, Neelu S, Dua K K. Time dependent preventive effects of simultaneous administration of selenium or zinc during mercury exposure in rats. Indian J Pharmacol [serial online] 1994 [cited 2020 Jun 1 ];26:209-212
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=3;spage=209;epage=212;aulast=Flora;type=0