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Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 204--208

Synthetic peptides related to the -receptors agonist, dermorphin

KM Sivanandaiah1, Babu Suresh2, HC Renukeshwar3, M Lakshmana4, MA Asif5, Chiplunkar Sunil6 
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Correspondence Address:
K M Sivanandaiah


Ten peptides related to the p-receptor agonist, dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2,) having structural modifications at positions 2,3.4 and 7 were synthesised by the solid phase method by using 9- fluorenylmethyloxycarbonyl (Fmoc)- amino acid trichlorophenyl (Tcp) ester as coupling agents and Merrifield resin as the solid support and their biological activities namely the effect on guinea pig ileum, the analgesic and the antidiarrhoeal activity were studied. The synthetic peptides were found to possess more antidiarrhoeal activity than any other activity and this is most pronounced in the analogues, (D- Met(O)2, MePhe3, Sar4, Tyr7) dermorphin and (D-Met(O)2 MePhe3, Sar4, Thr7) dermorphin.


How to cite this article:
Sivanandaiah K M, Suresh B, Renukeshwar H C, Lakshmana M, Asif M A, Sunil C. Synthetic peptides related to the -receptors agonist, dermorphin.Indian J Pharmacol 1994;26:204-208


How to cite this URL:
Sivanandaiah K M, Suresh B, Renukeshwar H C, Lakshmana M, Asif M A, Sunil C. Synthetic peptides related to the -receptors agonist, dermorphin. Indian J Pharmacol [serial online] 1994 [cited 2020 Jun 4 ];26:204-208
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=3;spage=204;epage=208;aulast=Sivanandaiah;type=0