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Year : 1994  |  Volume : 26  |  Issue : 1  |  Page : 49--51

Reduced phosphoinositide levels in endosulfan treated rat brain

A Subramoniam1, VK Khanna2, J Mohindra3, PK Seth4 
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Correspondence Address:
A Subramoniam


The influence of the insecticide, endosulfan on the levels of phosphoinositides in rat brain was studied. Single oral administration of endosulfan (15 mg/kg) to rats, after 4 hrs, reduced phosphatidylinositol (PI) and phosphatidylinositol 4,5-bisphosphate (PIP2), without any significant effect on phosphatidylinositol4-phosphate (PIP). On the other hand, daily administration of endosulfan (15 mg/kg) for 16 days caused a marked reduction in the levels of PIP2 and PI and a moderate reduction in PIP. These effects of endosulfan were restored to near normal levels 2 weeks after cessation of the treatment. When the dosage was reduced from 15 to 5 mg/kg daily endosulfan administration for 16 days slightly reduced the levels of PI - without any significant influence on the levels of PIP and PIP2. These studies suggest possible involvement of phosphoinositide messenger system in the neurotoxicity of endosulfan.


How to cite this article:
Subramoniam A, Khanna V K, Mohindra J, Seth P K. Reduced phosphoinositide levels in endosulfan treated rat brain.Indian J Pharmacol 1994;26:49-51


How to cite this URL:
Subramoniam A, Khanna V K, Mohindra J, Seth P K. Reduced phosphoinositide levels in endosulfan treated rat brain. Indian J Pharmacol [serial online] 1994 [cited 2019 Sep 21 ];26:49-51
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=1;spage=49;epage=51;aulast=Subramoniam;type=0