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Year : 1994  |  Volume : 26  |  Issue : 1  |  Page : 46--48

Anti-inflammatory activity of niosome encapsulated diclofenac sodium in arthritic rats

Naresh RA Raja1, GK Pillai2, N Udupa3, G Chandrashekar4 
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Correspondence Address:
Naresh RA Raja


Synthetic analogues of liposomes prepared from non-ionic surfactants, known as niosomes, have been used as vesicular drug carriers. Diclofenacsodium has been entrapped in niosomes comprising Tween 85 and Tween 85-poloxamer F 108 mixture. Anti- inflammatory efficacy of these niosomes were compared with that of free diclofenac sodium in adjuvant induced arthritic rats. It was found that the niosomal diclofenac sodium formulations prepared by employing a 1:l combination of Tween 85 and poloxamer F 108 elicits a better and consistent anti-inflammatory activity for more than 72 hours after administration of a single dose.


How to cite this article:
Raja NR, Pillai G K, Udupa N, Chandrashekar G. Anti-inflammatory activity of niosome encapsulated diclofenac sodium in arthritic rats.Indian J Pharmacol 1994;26:46-48


How to cite this URL:
Raja NR, Pillai G K, Udupa N, Chandrashekar G. Anti-inflammatory activity of niosome encapsulated diclofenac sodium in arthritic rats. Indian J Pharmacol [serial online] 1994 [cited 2020 Aug 12 ];26:46-48
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=1;spage=46;epage=48;aulast=Raja;type=0