Indian Journal of Pharmacology Home 

RESEARCH PAPER
[Download PDF]
Year : 1994  |  Volume : 26  |  Issue : 1  |  Page : 29--34

Gastric antiulcer activity of calcium channel blockers in rats

SM Jain1, NS Parmar2, DD Santani3 
1 
2 
3 

Correspondence Address:
S M Jain


This study has been undertaken to elucidate the possible mechanism of action of calcium channel blockers (CCBs) such as verapamil, nifedipine and diltiazem against experimentally induced gastric ulcers. The parameters studied include volume of gastric secretion, free and total acidity, pepsin activity, ulcer index, gastric wall mucus content, dissolved mucosubstances of gastric juice such as total carbohydrates (total hexose, hexosamine, fucose and sialic acid) and protein content of gastric juice using aspirin plus pylorus ligation (PL) model. CCBs significantly increased total carbohydrates of gastric juice. The protein content of gastric juice was significantly decreased. Thus a rise was observed in TC:PR ratio. Insoluble gastric wall mucus content was found to be increased in presence of CCBs. These results suggest that CCBs may act through prevention of gastric mucosal damage thereby strengthening the mucosal barrier


How to cite this article:
Jain S M, Parmar N S, Santani D D. Gastric antiulcer activity of calcium channel blockers in rats.Indian J Pharmacol 1994;26:29-34


How to cite this URL:
Jain S M, Parmar N S, Santani D D. Gastric antiulcer activity of calcium channel blockers in rats. Indian J Pharmacol [serial online] 1994 [cited 2019 Sep 20 ];26:29-34
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=1;spage=29;epage=34;aulast=Jain;type=0