Indian Journal of Pharmacology Home 

RESEARCH PAPER
[Download PDF]
Year : 1993  |  Volume : 25  |  Issue : 3  |  Page : 136--139

Studies on the mechanism of the hypothermic response to IDPH-791

AY Junnarkar1, PP Singh2, DS Shrotri3 
1 
2 
3 

Correspondence Address:
A Y Junnarkar


IDPH-791, a new central muscle relaxant, produced dose dependent hypothermia in mice. The possible mechanism involved in this response was investigated. Adrenergic blocking agents (prazosin, phenoxybenzamine, yohimbine and propranolol), dopaminergic antagonist (haloperidol), serotonergic antagonist (methysergide) and antihistamines (mepyramine and cimetidine) did not cause any significant modification of the hypothermia. Similarly prostaglandin synthesis inhibitors (ketoprofen, indomethacin and paracetamol) also did not alter the hypothermia induced by IDPH-791, thus ruling out the possibility of central prostaglandin involvement. Atropine reversed the hypothermic response and physostigmine potentiated it, suggesting the possible involvement of acetylcholine acting through muscarinic receptors. There was also significant increase in total acetylcholine content of rat brain on pretreatment with IDPH 791. It is concluded that central muscarinic receptor may be involved in the hypothermic response of IDPH-791.


How to cite this article:
Junnarkar A Y, Singh P P, Shrotri D S. Studies on the mechanism of the hypothermic response to IDPH-791.Indian J Pharmacol 1993;25:136-139


How to cite this URL:
Junnarkar A Y, Singh P P, Shrotri D S. Studies on the mechanism of the hypothermic response to IDPH-791. Indian J Pharmacol [serial online] 1993 [cited 2020 Sep 28 ];25:136-139
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1993;volume=25;issue=3;spage=136;epage=139;aulast=Junnarkar;type=0