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Year : 1993  |  Volume : 25  |  Issue : 2  |  Page : 99--100

Possible mechanism of antiinflammatory activity of Azadirachta indica leaf extract

RR Chattopadhyay1, RN Chattopadhyay2, SK Maitra3 
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Correspondence Address:
R R Chattopadhyay


Effect of Azadirachta indica (A.indica) leaf extract on inflammatory oedema induced by chemical mediators (5-HT, histamine, bradykinin and PGE1) was studied to find out its possible mechanism of reported antiinflammatory effect against carrageenin induced rat hind paw oedema. The test material showed significant antiinflammatory effect against 5-HT and PGE1 induced inflammation but not on the inflammation induced by histamine and bradvkinin. Median effective doses of A.indica for 5-HT and PGE1 induced oedema were 1.17g and 930 mg/ kg respectively. The result suggests that A.indica extract«SQ»s antiinflammatory effect may be due to antagonism of the deleterious effect of 5-HT and PGE1 on blood vessels.


How to cite this article:
Chattopadhyay R R, Chattopadhyay R N, Maitra S K. Possible mechanism of antiinflammatory activity of Azadirachta indica leaf extract.Indian J Pharmacol 1993;25:99-100


How to cite this URL:
Chattopadhyay R R, Chattopadhyay R N, Maitra S K. Possible mechanism of antiinflammatory activity of Azadirachta indica leaf extract. Indian J Pharmacol [serial online] 1993 [cited 2020 Jul 3 ];25:99-100
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1993;volume=25;issue=2;spage=99;epage=100;aulast=Chattopadhyay;type=0