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Year : 1992  |  Volume : 24  |  Issue : 3  |  Page : 174--175

Verapamil - A potential ocular hypotensive agent

SK Gupta1, HC Agarwal2 

Correspondence Address:
S K Gupta

The ocular hypotensive effect of a single topical application of verapamil was studied in albino rabbits. In normotensive rabbits, after base line measurement of intraocular pressure (IOP) with applanation tonometer, 30 l drops of verapamil in the concentration of 0.125% was instilled in one eye while contra-lateral eye received the vehicle and served as control. The IOP measurements were taken at 30 min., 2, 4 and 8 hrs. The onset of pressure lowering effect was observed at 30 minutes, with a peak effect at two hours and persisted up to 8 hrs. The hypotensive effect of verapamil was also studied after water loading in twelve rabbits. The reduction of pressure was more marked (6r1.20 vs 4 0.14 mm Hg) in water loaded rabbitSQs eyes as compared to normotensive eyes which was statistically significant (P < .001) when compared with base line values and with the contralaterarcontrol eyes.

How to cite this article:
Gupta S K, Agarwal H C. Verapamil - A potential ocular hypotensive agent.Indian J Pharmacol 1992;24:174-175

How to cite this URL:
Gupta S K, Agarwal H C. Verapamil - A potential ocular hypotensive agent. Indian J Pharmacol [serial online] 1992 [cited 2020 Aug 5 ];24:174-175
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