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Year : 1992  |  Volume : 24  |  Issue : 3  |  Page : 154--157

Toxicological profile of fluvalinate - A synthetic pyrethroid

SK Garg1, SK Rastogi2, VK Gupta3, C Varshneya4 
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Correspondence Address:
S K Garg


The effect of fluvalinate (15 mg/kg, i.p) on pentobarbitone induced hypnosis and spontaneous locomotor activity in mice revealed pronounced CNS depressant effect of the compound. It produced negative inotropic and chronotropiceffects on the isolated frog heart. Spontaneous motility of isolated chicken ileum was reduced by fluvalinate in dose dependent manner. Fluvalinate (15 mg/kg, i.p) treatment for 15 days resulted in significant reduction in total leucocyte and absolute lymphocyte count. The test compound when administered for 15 days @ 15 mg/kg/day i.p., produced hepato-nephro toxicity and mild peripheral disintegration of the lymphoid nodules in spleen.


How to cite this article:
Garg S K, Rastogi S K, Gupta V K, Varshneya C. Toxicological profile of fluvalinate - A synthetic pyrethroid.Indian J Pharmacol 1992;24:154-157


How to cite this URL:
Garg S K, Rastogi S K, Gupta V K, Varshneya C. Toxicological profile of fluvalinate - A synthetic pyrethroid. Indian J Pharmacol [serial online] 1992 [cited 2020 Jun 2 ];24:154-157
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1992;volume=24;issue=3;spage=154;epage=157;aulast=Garg;type=0