Indian Journal of Pharmacology Home 

SHORT COMMUNICATION
[Download PDF]
Year : 1992  |  Volume : 24  |  Issue : 2  |  Page : 121--122

5-HT link in imipramine induced hypothermia in rabbits

AK Srivastava1, YP Srivastava2, PP Gupta3, RB Verma4 
1 
2 
3 
4 

Correspondence Address:
A K Srivastava


The effect of imipramine and 5-HT linked agents on body temperature was studied in rabbits. The drugs were administered intracerebroventricularly (icv) and rectal temperature was recorded. Graded doses of imipramine produced dose related hypothermia. Methysergide (200 ęg icv) alone produced hyperthermia and completely blocked the hypothermia produced by 500 ęg of imipramine. The pretreatment with p-chlorophenylalanine (25 mg/day, i.p; 3 days) completely abolished the hypothermia produced by 500ęg of imipramine. It appeared that 5-HT is involved in the production of hypothermia induced by imipramine.


How to cite this article:
Srivastava A K, Srivastava Y P, Gupta P P, Verma R B. 5-HT link in imipramine induced hypothermia in rabbits.Indian J Pharmacol 1992;24:121-122


How to cite this URL:
Srivastava A K, Srivastava Y P, Gupta P P, Verma R B. 5-HT link in imipramine induced hypothermia in rabbits. Indian J Pharmacol [serial online] 1992 [cited 2020 Aug 12 ];24:121-122
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1992;volume=24;issue=2;spage=121;epage=122;aulast=Srivastava;type=0