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Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 361--366

Morphine dependence and withdrawal in rat: role of dopamine

ZY Khan1, PC Dandiya2 
1 
2 

Correspondence Address:
Z Y Khan


Dependence was induced in rats by repeated intraperitoneal injections of morphine sulfate withdrawal signs were precipitated by subcutaneous injection of naloxone. The dopamine agonists, i.e, apomorghine d-amphetamine and I-dopa aggravated the withdrawal signs while synthesis inhibitors / depletors of dopamine, i.e, reserpine and DL-a-methyl-p-tyrosine prevented the occurrence of almost all the withdrawal signs. These findings suggest the involvement of dopamine in the production of morphine dependence and withdrawal.


How to cite this article:
Khan Z Y, Dandiya P C. Morphine dependence and withdrawal in rat: role of dopamine.Indian J Pharmacol 1983;15:361-366


How to cite this URL:
Khan Z Y, Dandiya P C. Morphine dependence and withdrawal in rat: role of dopamine. Indian J Pharmacol [serial online] 1983 [cited 2020 Apr 2 ];15:361-366
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1983;volume=15;issue=4;spage=361;epage=366;aulast=Khan;type=0