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Year : 1983  |  Volume : 15  |  Issue : 3  |  Page : 235--240

Gastric tissue histamine concentration in 48/80 compound treated albino rats

AK Ganguly1, KB Solanki2, AK Mathur3, K Somasundaram4 
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Correspondence Address:
A K Ganguly


A single 4 ęg/g injection of 48/80 markedly reduced the gastric tissue histamine concentration in albino rats within 3 h. While gastric tissue histamine concentration was shown to be within normal limits, 18 h after a single dose of 4 ęg/g body weight of 48/80, the same was very high 18 after injections of lower doses. A rise in gastric tissue histamine concentration was also observed 18 h after two consecutive, 4 ęg/g or lower doses of 48/80 with an interval of 7 h between them. Following three 4 ęg/g doses of 48/80 with suitable intervals between them, the gastric tissue histamine concentration was shown to very high even 3 h after the last injection. The findings suggest that following a single standard dose of 48/80 the gastric wall not only become shypo or unresponsive to histamine releasing effect of subsequent doses of 48/80, the later enhances synthesis of histamine in the gastric wall. 48/80 in lower doses also stimulates histamine synthesis in the gastric wall possibly after its initial histamine releasing effect dies down.


How to cite this article:
Ganguly A K, Solanki K B, Mathur A K, Somasundaram K. Gastric tissue histamine concentration in 48/80 compound treated albino rats.Indian J Pharmacol 1983;15:235-240


How to cite this URL:
Ganguly A K, Solanki K B, Mathur A K, Somasundaram K. Gastric tissue histamine concentration in 48/80 compound treated albino rats. Indian J Pharmacol [serial online] 1983 [cited 2020 Sep 23 ];15:235-240
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1983;volume=15;issue=3;spage=235;epage=240;aulast=Ganguly;type=0