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Year : 1983  |  Volume : 15  |  Issue : 3  |  Page : 165--170

Effect of L-Dopa, amantadine and tremorine on brain monamines

SD Seth1, BP Srinivasan2, HH Siddiqui3, SP Sivam4 
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Correspondence Address:
S D Seth


The effect of L-dopa, alone and in combination, on brain dopamine, norepinephrine, serotonin, 5-hydroxyindole acetic acid and monoamine oxidase activity was investigated in tremorine induced tremor syndrome in rats. L-dopa, alone and in combination with amantadine, produced a remarkable rise in dopamine and 5-hydroxyindole acetic acid and a reduction in serotonin content.Tremorine failed to influence any of the parameters. The findings suggest that L-dopa and amantadine have pro-found effects on brain biogenic amines which may account for the therapeutic effects as well as behavioural side-effects frequently encountered in clinical practice.


How to cite this article:
Seth S D, Srinivasan B P, Siddiqui H H, Sivam S P. Effect of L-Dopa, amantadine and tremorine on brain monamines.Indian J Pharmacol 1983;15:165-170


How to cite this URL:
Seth S D, Srinivasan B P, Siddiqui H H, Sivam S P. Effect of L-Dopa, amantadine and tremorine on brain monamines. Indian J Pharmacol [serial online] 1983 [cited 2020 Jun 2 ];15:165-170
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1983;volume=15;issue=3;spage=165;epage=170;aulast=Seth;type=0